Throw away the medicine after 6 weeks have passed since you first opened the bottle. Tilt your head back a little and pull the lower lid of your eye downwards to form a pocket. (One study found a diurnal mean IOP-lowering of 19.8 percent when the two drug classes were combined, versus 14 percent with latanoprost alone, and a nocturnal mean IOP-lowering of 13.4 percent with the combination versus 10 percent with latanoprost alone. The subjects enrolled to the study were randomly assigned to receive either latanoprost stored at 4 degrees C or that stored at 30 degrees C. The eye drop was applied to the right eye of each subject for 3 days. Dosage. It's best to do this is in the evening as latanoprost works better then. Conclusions: : Latanoprost effectively lowers IOP during the day and night with once nightly administration. Xalatan (latanoprost) can also cause some eye redness which is minimized with nightly dosing. Remember to use it at the same time each day. When patients are diagnosed with glaucoma, one of the most common treatment options is a prescription eye drop medication that lowers eye pressure, which prevents damage to the optic nerve and helps to preserve vision. The usual dose for adults and children is 1 drop into the affected eye(s) once a day. How to use latanoprost eye drops. Store an unopened bottle of latanoprost eye drops in a refrigerator. Always use latanoprost eyedrops exactly as your doctor told you. 1 doctor agrees. Do not freeze. Answered on Aug 26, 2012. The company producing the medication also recommends this dosing. 0. The phase IV clinical study is created by eHealthMe based on reports of 18,555 people who have side effects when taking Latanoprost from the FDA, and is updated regularly. The IOP reduction can be explained by an increase in uveoscleral outflow. Open the bottle, or if you are using a single-use dose unit, remove the tip of the unit. In a crossover study in 20 subjects, his group evaluated the IOP-lowering efficacy of a beta-blocker (timolol maleate), a topical carbonic anhydrase inhibitor (dorzolamide) and a prostaglandin analogue (latanoprost).10 IOP was measured every three hours around the clock, including midnight, 3:00 a.m. and 6:00 a.m. Use this medication regularly in order to get the most benefit from it. Either is fine: Using the medicine is more important than when it is used. Xalatan (latanoprost): Capstan is used at night because it is most effective when used every evening. After your first use, store the eye drops at room temperature away from moisture, heat, and light. How to use eyedrops. Keep the bottle tightly closed when not in use. Hold the bottle or single-use dose unit upside down near to your eye. Night sweats is found among people who take Latanoprost, especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months. Why is Latanoprost taken at night? 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