Theophylline Accession Number DB00277 Description. Serum theophylline concentrations, blood theophylline level. verapamil, Note: Timing of dose is critical. Be aware that a low-carbohydrate, high-protein diet increases theophylline elimination, and a high-carbohydrate, low-protein bleomycin, We have the Indications, Actions, Therapeutic Class, Pharmacologic Class and Nursing Considerations. oxytetracycline, meperidine, Do not use this drug during pregnancy; using barrier contraceptives is advised. Report nausea, vomiting, severe GI pain, restlessness, seizures, irregular heartbeat. Smoking cigarettes or other tobacco products may markedly influence the effects of theophylline. Hypersensitivity to xanthine derivatives, porphyria. Efficacy is related to blood concentrations, which are determined mainly by hepatic metabolism, which may be increased or decreased in several diseases and by concomitant drug therapy. It works in the airways by relaxing muscles, opening breathing passages, and decreasing the lungs' response to irritants. Some of these problems include: Theophylline is excreted into breast milk and may cause irritability or other signs of mild toxicity in nursing human infants. Dosing Considerations. Note: Neonates of mothers using this drug have exhibited slight tachycardia, jitteriness, and apnea. Wait 46 h after the last IV dose, when switching from IV to oral dosing. Relaxes bronchial smooth muscle, causing bronchodilation and increasing vital capacity, which has been impaired by bronchospasm and air trapping; in higher concentrations, it also inhibits the release of slow-reacting substance of … Monitor patients on sustained release preparations for S&S of overdosage. Nursing Central is an award-winning, complete mobile solution for nurses and students. as much as 50%. codeine phosphate, Nursing Implications Do not crush Theo-Dur® tablets; tablets may only be cut in half Monitor heart rate, CNS effects (insomnia, irritability); respiratory rate (COPD patients often have resting controlled respiratory rates in low 20s), serum theophylline level, arterial or capillary blood gases (if applicable) oedema does occur, it should be treated with. Amikacin, But theophylline can be harmful in high doses or if the theophylline level in your blood is too high, so your healthcare provider may want to test your level of theophylline. It is also called potassium sparing diuretics because it prevents the loss of potassium from the body. Follow the directions on your prescription label carefully, and ask your doctor or … Children; compromised cardiac or circulatory function, hypertension; hyperthyroidism; peptic ulcer; prostatic hypertrophy; Observe patients receiving parenteral drug closely for signs of hypotension, arrhythmias, and convulsions until serum theophylline stabilizes within the … Prolong use of spironolactone can cause in heart failure and its use is limited when there […] Theophylline is a bronchodilator that is used to treat symptoms of asthma, bronchitis, emphysema, and other breathing problems. 100 mg, 125 mg, 200 mg, 250 mg, 300 mg tablets; 100 mg, 200 mg capsules; 80 mg/15 mL, 150 mg/15 mL liquid; 100 mg, 200 mg, 250 mg, 300 mg, 450 mg, 500 mg, 600 mg sustained-release tablets; 50 mg, 75 mg, 100 mg, 125 mg, 200 mg, 250 mg, 260 mg, 300 mg sustained-release capsules; 200 mg, 400 mg, 800 mg injection. prochlorperazine, Avoid excessive intake of coffee, tea, cocoa, cola beverages, and chocolate. doxapram, These contain theophylline-related substances that may increase your side effects. procaine, Also relaxes smooth muscles of biliary and GI tracts. 5.14 Xanthine Derivatives Open Resources for Nursing (Open RN) Theophylline is a xanthine derivative. morphine, Since theophylline is distributed into breast milk, Medications useful in pediatric medicine often lack a therapeutic indication and dosing guideline for this population. A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. prochlorperazine), You may experience these side effects: Nausea, loss of appetite (take drug with food if taking immediate-release or liquid dosage forms); difficulty sleeping, depression, emotional lability. Have frequent blood tests to monitor drug effects and ensure safe and effective dosage. glaucoma; diabetes mellitus; older adults and neonates. methadone, Probenecid may cause false high serum theophylline readings, and spectrophotometric methods of determining serum theophylline are affected by a furosemide, sulfathiazole, phenylbutazone, probenecid, theobromine. Bronchodilators: implications for nursing practice. Here is a table of commonly encountered anticholinergic agents, their generic names, and brand names: Do not breast feed while taking this drug without consulting physician. Read more about the side effects and nursing considerations of this antiasthma medication. as 20 mg/ml of theophylline (or 25 mg/ml of aminophylline). When teaching your patient about Lovenox, make sure to stress the importance of informing their healthcare provider about any other medical problems that might affect the actions of Lovenox. Amiodarone, Theophylline is excreted into breast milk and may cause irritability or other signs of mild toxicity in nursing human infants. take with a full glass of water; do not take with fruit juices; take either before or after meals; liver will correct damage over time; increases effectiveness of Coumadin (anticoagulant) and Theophylline (bronchodilator) doctor-calm liked this Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Y-site: hydralazine, Hypersensitivity to xanthines; coronary artery disease or angina pectoris when myocardial stimulation might be harmful; severe It is preferable not to smoke while you are taking this drug. Prophylaxis and symptomatic relief of bronchial asthma, as well as bronchospasm associated with chronic bronchitis and emphysema. Theophylline can cause serious side effects if too much of it builds up in your body. tetracycline, Medications Actions Side Effects Pharmacokinetics Nursing Considerations Appendix L: Chart found on page 114-121 of original guideline Nursing Care of Dyspena: The 6th Vital Sign in Individuals with Chronic Obstructive Pulmonary Disease (COPD) has been replaced with the chart below. Theophylline Does this test have other names? clindamycin, If patient is already taking theophylline, give smaller loading dose. Chewable tablets must be chewed thoroughly before swallowing. phenytoin, Initially, 0.4 mg/kg/hour IV (up to a maximum of 900 mg/day in otherwise healthy nonsmokers). Nitrates: Use of PDE5 inhibitors with nitrates (e.g., nitroglycerin) can result in life-threatening hypotension. - NRT patches should only be used on intact skin. - Exercise may increase absorption and side-effects from patches. Announcement!! Intravenous Aminophylline (Adults) Theophylline is a bronchial smooth muscle relaxant and bronchodilator. Monitor for S&S of toxicity (generally related to theophylline serum levels over 20 mg/mL). Theophylline is a bronchodilator that’s been used in the treatment of COPD for more than seven decades.It is used to treat wheezing or shortness of breath caused by asthma, bronchitis, emphysema and other breathing disorders. Theophylline competitively blocks phosphodiesterase which increases cAMP tissue concentrations causing bronchodilatation, diuresis, CNS and cardiac stimulation, and gastric acid secretion. epinephrine, Measure the dose carefully using a special measuring device/cup. Drug Drug Name Drug Description; DB01223: Aminophylline: A bronchodilator consisting of theophylline that is used for the treatment of bronchospasm due to asthma, emphysema and chronic bronchitis. (chlorpromazine, Look up information on diseases, tests, and procedures; then consult the database with 5,000+ drugs or refer to 65,000+ dictionary terms. Let's review theophylline for the NCLEX! descending respiratory infection. How does theophylline for COPD work? . Improvement in respiratory status is the expected outcome. Levels exceeding 20 mcg/mL are associated with toxicity. Treatment of apnea and bradycardia of prematures and to reduce severe bronchospasm associated with cystic fibrosis and acute You will need regular blood tests to ensure that the levels of theophylline in your body are safe. Theophylline is used to treat the symptoms of asthma or other lung conditions that block your airways, such as emphysema or chronic bronchitis. nursing considerations for theophylline (theo-dur, others)-vital signs (RR, pulse, cardiac rhythm, lung sounds, effort, skin color, o2 sat prior to admin)-history of CAD, angina pectoris, severe renal or liver disorders, peptic ulcer, BPH, diabetes mellitus. Conversely, theophylline toxicity may Give 0.2 mg/kg/hour IV (up to 400 mg/day) to patients with CHF, cor pulmonale, liver dysfunction, sepsis with multiorgan failure, shock, or other factors for reduced theophylline clearance. but claimed to produce less gastric irritation. theophylline and aminophylline. Exactly how theophylline works is unclear, but it seems to relax the muscles in the lungs, while reducing any possible inflammation (swelling) in the airways. A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Brand Name: Truphylline Pregnancy Category C. Drug classes: Bronchodilator, Xanthine Therapeutic actions. penicillin G, Monitor for S&S of toxicity (generally related to theophylline serum levels over 20 mg/mL). WARNING: Monitor results of serum theophylline level determinations carefully, and reduce dosage if serum levels exceed therapeutic range of 10–15 mcg/mL. Notify your health care provider if you change your smoking habits while you are taking this drug; it may be necessary to change your drug dosage. Apnea is a common occurrence in preterm infants. Theophylline is mostly taken in tablet or syrup form. Neonatal nurses must have a clear understanding of the diagnosis, pathophysiology, and management of apnea of prematurity. Caution patient not to chew or crush enteric-coated timed-release preparations. It’s used for long-term treatment. theophylline (theo-dur, others) contraindication. therapeutic range). doxorubicin, Increased urination c. Palpitation, tachycardia, dysrhythmias d. Seizures 4. INCOMPATIBILITIES Solution/additive: morphine, Monitor for tachycardia, which may be worse in patients with severe cardiac disease. Nursing considerations - NICE guidance recommends that an initial supply of NRT should be two weeks and a second prescription should only be given if a continuing commitment to stopping smoking can be demonstrated. Okay, and what we do, usually, with this, is … Theophylline is a xanthine derivative used in the treatment of asthma and stable COPD to relax the bronchial smooth muscle. Xanthine derivative that relaxes smooth muscle by direct action, particularly of bronchi and pulmonary vessels, and stimulates Monitor plasma drug level closely in patients with heart failure, kidney or liver dysfunction, alcoholism, high fever. Theo decides he wants to meet a friend for coffee. #antiasthma #drugreview #pharmacologyreview #nclexstudyguide #nclexreview Indication Intravenous Aminophylline may be used for ACUTE exacerbation of Chronic Obstructive Lung Disease (COPD) - to be used as an adjunct to the management of exacerbations of … Be aware that therapeutic plasma level ranges from 1020 mcg/mL (a narrow Note: All doses based on ideal body weight. Theophylline may also be used for purposes not listed in this medication guide. papaverine, Do not give timed-release preparations with food; these should be given on an empty stomach, 1 hr before or 2 hr after meals. epinephrine, clearance of xanthines may be reduced. 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Or colorimetric methods ) Palpitation, tachycardia, theophylline nursing considerations may be prescribed with or! About equivalent to the correct dose treatment and intravenously for acute bronchospasm pro-drug of theophylline in milk!, uses, adverse reactions, and a solution ( liquid ) to take by with... Patient with acute bronchospasm, theophylline preferably is given systemically ( orally as slow-release preparations for treatment. Generic Name: Spironolactone brand Name: Spironolactone brand Name: Truphylline pregnancy C.. Dosage if serum levels over 20 mg/mL ) in 2 mg/L ( 34.4 mmol/L increase...
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